2. Signaling Pathways
  3. Membrane Transporter/Ion Channel
    Neuronal Signaling
  4. TRP Channel

TRP Channel

Transient receptor potential channels

TRP Channel

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TRP Channel (Transient receptor potential channel) is a group of ion channels located mostly on the plasma membrane of numerous human and animal cell types. There are about 28 TRP channels that share some structural similarity to each other. These are grouped into two broad groups: Group 1 includes TRPC ("C" for canonical), TRPV ("V" for vanilloid), TRPM ("M" for melastatin), TRPN, and TRPA. In group 2, there are TRPP ("P" for polycystic) and TRPML ("ML" for mucolipin). Many of these channels mediate a variety of sensations like the sensations of pain, hotness, warmth or coldness, different kinds of tastes, pressure, and vision. TRP channels are relatively non-selectively permeable to cations, including sodium, calcium and magnesium. TRP channels are initially discovered in trp-mutant strain of the fruit fly Drosophila. Later, TRP channels are found in vertebrates where they are ubiquitously expressed in many cell types and tissues. TRP channels are important for human health as mutations in at least four TRP channels underlie disease.

TRP Channel Isoform Specific Products:

TRP Channel Isoform Comparison
Cat. No. Product Name Effect Purity Chemical Structure
  • HY-142214
    TRPA1-IN-1
    		Antagonist
    TRPA1-IN-1 is a potent, selective, and orally bioavailable TRPA1 small molecule antagonist.
    TRPA1-IN-1
  • HY-111494
    TRPA1 Antagonist 1
    		Inhibitor
    TRPA1 Antagonist 1 is a methylene phosphate proagent which converts to its active parent agent, a TRPA1 antagonist with an IC50 of 8 nM.
    TRPA1 Antagonist 1
  • HY-114400A
    TRPV4 agonist-1
    		Agonist
    TRPV4 agonist-1 is a transient receptor potential vanilloid 4 (TRPV4) agonist with an EC50 of 60 nM in the hTRPV4 Ca2+ assay[1].
    TRPV4 agonist-1
  • HY-16162
    D-3263
    		Agonist
    D-3263 is an agonist of transient receptor potential melastatin member 8 (TRPM8) with potential antineoplastic activity.
    D-3263
  • HY-112202
    GSK3395879
    		Antagonist
    GSK3395879 is a selective and orally bioavailable transient receptor potential vanilloid-4 (TRPV4) antagonist with an IC50 of 1 nM for hTRPV4.
    GSK3395879
  • HY-P10762
    CBP-1008
    		Ligand
    CBP-1008 is a dual-ligand peptide-drug conjugate (PDC) conjugated to MMAE (HY-15162), targeting Folate receptor α (FRα) and TRPV6. CBP-1008 binds to FRα with high affinity and TRPV6 with low affinity. CBP-1008 has antitumor activity, and can be used in advanced solid tumor research (eg: colorectal cancer, breast cancer, non-small cell lung cancer, ovarian cancer, adrenocortical carcinoma and follicular dendritic cell sarcoma).
    CBP-1008
  • HY-P10740
    CBP-1018
    CBP-1018 is a PDC (peptide drug conjugate) consisting of a dual targeting FRα/TRPV6 ligand (blue part) coupled to Monomethyl auristatin E (HY-15162) (red part) via a linker (HY-78738) (black part). CBP-1018 is expected to be used in breast cancer research.
    CBP-1018
  • HY-112298
    DS88790512
    		Inhibitor
    DS88790512 is a potent, selective, and orally bioavailable TRPC6 inhibitor with an IC50 of 11 nM.
    DS88790512
  • HY-10448S1
    Capsaicin-d3
    		Agonist
    Capsaicin-d3 is the deuterium labeled Capsaicin. Capsaicin ((E)-Capsaicin), an active component of chili peppers, is a TRPV1 agonist. Capsaicin has pain relief, antioxidant, anti-inflammatory, neuroprotection and anti-cancer effects[1][2].
    Capsaicin-d<sub>3</sub>
  • HY-131897S
    1-Stearoyl-2-Arachidonoyl-d8-sn-Glycerol
    		Activator
    1-Stearoyl-2-Arachidonoyl-d8-sn-Glycerol is the deuterium labeled 1-Stearoyl-2-arachidonoyl-sn-glycerol. 1-Stearoyl-2-arachidonoyl-sn-glycerol is a diacylglycerol (DAG) containing polyunsaturated fatty acids. 1-Stearoyl-2-arachidonoyl-sn-glycerol can activate PKC. 1-Stearoyl-2-arachidonoyl-sn-glycerol also can augment nonselective cation channel (NSCC) activity[1][2].
    1-Stearoyl-2-Arachidonoyl-d<sub>8</sub>-sn-Glycerol
  • HY-114524S
    (E)-4-Oxo-2-nonenal-d3
    (E)-4-Oxo-2-nonenal-d3 is the deuterium labeled (E)-4-Oxo-2-nonenal[1].
    (E)-4-Oxo-2-nonenal-d<sub>3</sub>
  • HY-157766
    FAAH/TRPV1 blocker-1
    		Inhibitor
    FAAH/TRPV1 blocker-1 (compound 2R) is a dual FAAH/TRPV1 blocker, with IC50 of 0.12 and 94.9 μM, respectively. FAAH/TRPV1 blocker-1 plays an important role in analgesic and anti-inflammatory research.
    FAAH/TRPV1 blocker-1
  • HY-N7117R
    1,4-Cineole (Standard)
    		Activator
    1,4-Cineole (Standard) is the analytical standard of 1,4-Cineole. This product is intended for research and analytical applications. 1,4-Cineole is a widely distributed, natural, oxygenated monoterpene. 1,4-Cineole, present in Rhododendron anthopogonoides, activates both human TRPM8 and human TRPA1.
    1,4-Cineole (Standard)
  • HY-110189S1
    Pregnenolone monosulfate-d4 sodium
    		Activator
    Pregnenolone monosulfate-d4 (sodium) is the deuterium labeled Pregnenolone monosulfate. Pregnenolone monosulfate sodium (3β-Hydroxy-5-pregnen-20-one monosulfate sodium) is a powerful neurosteroid, the main precursor of various steroid hormones including steroid ketones. Pregnenolone monosulfate sodium acts as a signaling-specific inhibitor of cannabinoid CB1 receptor, inhibits the effects of tetrahydrocannabinol (THC) that are mediated by the CB1 receptors. Pregnenolone monosulfate sodium can protect the brain from cannabis intoxication[1][2]. Pregnenolone monosulfate sodium is also a TRPM3 channel activator, and also can weakly activate TRPM1 channels[3].
    Pregnenolone monosulfate-d<sub>4</sub> sodium
  • HY-N7965
    Methyl kakuol
    		Agonist
    Methyl kakuol shows agonistic activity against TRPA1 with an EC50 of 0.27 µM.
    Methyl kakuol
  • HY-W790266
    Polygodial pyridazine
    		Agonist
    Polygodial pyridazine (compound 7) is a polygodial analogue and a TRPV1 agonist with a GI50 of 72 μM against MCF-7. Polygodial pyridazine can be utilized in cancer research.
    Polygodial pyridazine
  • HY-168608
    TRPM7-IN-1
    		Inhibitor
    TRPM7-IN-1 (compound SUD), a benzoylurea derivative, is an effective TRPM7 inhibitor. TRPM7-IN-1 induces cell cycle arrest and apoptosis, decreases the migration of MCF-7 and BGC-823 cells. TRPM7-IN-1 decreases vimentin expression and increases E-cadherin expression. TRPM7-IN-1 potentially reduces the TRPM7-like current and decreases TRPM7 expression through the PI3K/Akt signaling pathway. TRPM7-IN-1 is a potential agent to suppress the metastasis of breast and gastric cancer by inhibiting TRPM7 expression and function.
    TRPM7-IN-1
  • HY-149823
    TRPV4 antagonist 4
    		Antagonist
    TRPV4 antagonist 4 is a potent TRPV4 antagonist with an IC50 value of 22.65 nM. TRPV4 antagonist 4 inhibits TRPV4 current. TRPV4 antagonist 4 shows protective effects on acute lung injury.
    TRPV4 antagonist 4
  • HY-111036
    AMG0347
    		Antagonist
    AMG0347 is a transient receptor potential type V1 receptor antagonist. AMG0347 inhibits activation of the rat TRPV1 channel by heat (IC50 = 0.2 nm), protons (IC50= 0.8 nm), or capsaicin (IC50 = 0.7 nm).
    AMG0347
  • HY-19589
    JTS-653
    		Antagonist
    JTS-653 is a highly potent and selective transient receptor potential vanilloid 1 (TRPV1) antagonist in vitro and in vivo. JTS-653 attenuates chronic pain refractory to non-steroidal anti-inflammatory agents.
    JTS-653
Cat. No. Product Name / Synonyms Application Reactivity
TRP Channel Isoform Comparison

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